In rebuilding Tianjin Metro CFD simulations are performed to evaluate the original design of the ventilation system of Southwest Station and a new system is given to optimize the velocity and temperature fields at the station. Field measurements are conducted to validate the turbulence model and acquire boundary conditions. It is found that two-equation turbulence model is acceptable in simulating complex flow at the station. A method of simplifying the simulation of the transient flow at the station into steady flow is used and the validation criterion for this simulation is also given.